To improve data quality in experimental pig research, the PIGWEB project has established comprehensive guidelines for experimental design. These PIGWEB guidelines integrate existing resources (e.g., books and journals), methodologies used by PIGWEB partners, challenges faced by pig researchers, and power analyses based on PIGWEB partners' data. Presented as seven key principles, the guidelines aim to enhance the quality, reproducibility, and reliability of pig research by promoting more rigorous and standardized experimental design practices within the pig research community.