Published October 2, 2024 | Version v1
Poster Open

Multienzymatic cascades for environmentally sustainable processes

Description

The design and implementation of sustainable processes, which are not dependent on fossil
fuels, represents a significant challenge in the coming years [1]. However, biocatalytic processes
based on one enzymatic step limit the potential range of molecules that can be produced. A
clear trend is emerging towards the development of new and sophisticated biocatalytic
cascades, which will replace single-step enzymatic transformations, allowing a cost-effective
production of complex molecules while expanding the range of compounds that can be
enzymatically obtained. However, further progress is required to industrially implement these
systems such as improvements in process metrics, robustness and flexibility. In addition, a
reduction in the biocatalysts production costs is also required to enhance the techno-economic
feasibility of the processes.

The group of Bioprocess Engineering and Applied Biocatalysis aims to address these
challenges through the economic and sustainability-oriented design, preparation, and
implementation of biocatalysts. This goal is achieved through the implementation of an
integrated and multidisciplinary approach, involving the production, the
purification/immobilization of enzymes in a single step [2], as well as the design of self-
sufficient biocatalysts for their use in enzymatic reactors.

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Additional details

Funding

OXIPRO – Transition towards environment-friendly consumer products by co-creation of an oxidoreductase foundry 101000607
European Commission