Antibiotic resistant pathogens have been declared by WHO as one of the major public health threats facing humanity.  For that reason, there is an urgent need for materials with inherent antibacterial activity able to replace the use of antibiotics, and in this context, hydrogels have emerged as a promising strategy. Herein, we introduce the next generation of cationic hydrogels with antibacterial activity and high versatility that can be cured on demand in less than twenty seconds by using Thiolene Click Chemistry (TEC) in aqueous conditions. The approach capitalizes on a two-component system: i) telechelic polyester based Dendritic-Linear-Dendritic (DLDs) block copolymers of different generations heterofunctionalized with allyl and ammonium groups, as well as ii) polyethylene glycol (PEG) crosslinkers functionalized with thiol groups. These hydrogels resulted in highly tunable materials where the antibacterial performance can be adjusted by modifying the crosslinking density. Off-stoichiometric hydrogels showed narrow antibacterial activity directed towards Gram-negative bacteria. The presence of pending allyls opens up many possibilities for functionalization with biologically interesting molecules.  As a proof-of-concept, hydrophilic cysteamine hydrochloride as well as N-hexyl-4-mercaptobutanamide, as an example of a thiol with a hydrophobic alkyl chain, generated three-component networks. In the case of cysteamine derivatives, a broader antibacterial activity was noted than the two-component networks, inhibiting also the growth of Gram-positive bacteria. Additionally, these systems presented high versatility, with storage modulus values ranging from 270 to 7024 Pa and different stability profiles ranging from 1 to 56 days in swelling experiments. Good biocompatibility towards skin cells as well as strong adhesion to multiple surfaces, place these hydrogels as interesting alternatives to conventional antibiotics.