Published March 10, 2024
| Version v1
Poster
Open
Development and application of an immunocompetent human induced pluripotent stem cell-derived intestinal epithelial cell model for hazard assessment of the oral exposure route
Creators
- 1. Wageningen Food Safety Research, Wageningen, The Netherlands
- 2. Wageningen Food & Biobased Research, Wageningen, The Netherlands
Description
Human induced pluripotent stem cell (hiPSC)-derived intestinal epithelial cell (IEC) layers have the potential to provide an increasingly improved alternative to cell lines as they differentiate into multiple intestinal cell types that are also present in vivo. However, these models currently lack immunocompetence, as they do not contain immune cells like for instance dendritic cells (DCs) that play an important role in intestinal immune responses.
Files
SOT_poster_2024_WFSR.pdf
Files
(1.2 MB)
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