SAbyNA D3.1 Identification and selection of existing resources for hazard assessment of NFs/NEPs
Description
The aim of H2020 SAbyNA Task 3.1 (T3.1) has been to distil existing data, methods, models and tools, relating to hazard
assessment. The resources evaluated have included computational models, databases, risk assessment (RA)
tools, and hazard assessment methods, each in respect to both human and environmental exposure. Their
relevance in terms of context and their purpose in supporting Safe by Design (SbD) approaches for
nanotechnology have been considered during the analysis process.
Following the criteria selection in Milestone 3.1, four data resources have been considered appropriate for use
in the continuation of WP3, including eNanoMapper, NanoCommons platform, MESOCOSM database and a
non-EU data source Pubvinas, and ten RA tools were identified as being useful in assessing and providing
hazard information. In general, these RA tools were found to be lacking when considering their usefulness for
SbD approaches, and as such it was decided to extract relevant approaches from these tools to further develop the GUIDEnano tool within SAbyNA. From these tools, a number of important hazard descriptors and hazard
predicting parameters have been identified (e.g. solubility, oxidative potential, inflammatory reactions and
morphology); a number of standardised methodologies have been collected that can assess these hazard
descriptors, and it is these that will provide the base for further development in Task 3.2.
Key considerations for development of hazard approaches in WP3 include the reliability of the thresholds used
during RA, and how informative these thresholds may be, how to best use read-across to inform in SbD selection
processes, and how robust are the selected test methods when considering the materials relevant for the
SAbyNA case studies.
Files
D3.1 – Identification and selection of existing resources for hazard assessment of NFs NEPs.pdf
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(2.9 MB)
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