supplementary data Designing and Evaluation of Ebastine –Benzamide Cocrystals

Fig (1) Ebastine  chemical imaging by raman spectroscopy

Fig (2) benzamide  chemical imaging by raman spectroscopy

Fig (3) Ebastine- Benzanide (1_8) molar ratiophysical mixture  chemical imaging by raman spectroscopy

Fig (4) Ebastine- Benzanide (1_8) molar ratio cocrystal  chemical imaging by raman spectroscopy

Fig (5) SEM of ebastine

Fig (5) SEM of benzamide

Fig (6) SEM of Ebastine- Benzanide (1_8) molar ratio cocrystal 

Fig (7) ebastine structure by Avogadro  software

Fig (8)  BENE structure by Avogadro software

Fig (9) EB-BENZ cocrystal (1-8) molar ratio

Fig(10) release profile of cocrystal in EB-BENZ  (1-4) molar ratio in a different method

Fig(11) release profile of cocrystal in EB-BENZ  (1-8) molar ratio in a different method

fig(12) optical microscope (a)EB(b) BENZ(c)EB-BENZ3(SE)(d)EB- BENZ6slurry(e) EB-BENZ9(LAG)