Recurrent/Disseminated Choroid Plexus Carcinoma: Overall Survival of > 23.6 Years in a One-Year and Nine-Month-Old Female Treated with Antineoplastons.

 

Choroid plexus neoplasms (CPNs) are uncommon and have three types: papilloma, atypical papilloma, and carcinoma (CPC). There is no established treatment for recurrent/disseminated CPC. Objectives: CPN patients received treatment at the Burzynski Clinic (BC) according to the phase II protocol, BT-26, which aimed to evaluate the antitumor activity of ANP and to evaluate patient tolerance to ANP. Tumor response was assessed by sequential brain and spine MRIs utilizing gadolinium enhancement. Findings: After gross total resection of her CPC at another facility, this one-year and nine-month-old child, along with her parents, came to the BC for evaluation and treatment of the child’s recurrent/disseminated CPC. Baseline MRI of the brain (September 15, 2000) showed four enhancing lesions totaling 2.16 cm² in size. Baseline MRI of the spine (August 28, 2000) showed enhancing but non-measurable dural lesions. Subsequent MRIs (December 14, 2000) showed enhancing brain tumors totaling 3.03 cm² in size (a 40.3% increase from baseline) and enhancing dural lesions of the spine totaling 0.81 cm² in size, indicating progressive disease. However, following ANP, this child has enjoyed > 23.6 years overall survival while experiencing good health. Conclusions: A very rare long-term survival with recurrent/disseminated CPC is presented and the usefulness of ANP is discussed.