in-Silico TRials guide optimal stratification of ATrIal FIbrillation patients to Catheter Ablation vs pharmacological medicaTION: The i-STRATIFICATION Study
Description
This dataset includes the meshes of ten atrial anatomies (AA) ready for simulation using MonoAlg3D (https://github.com/rsachetto/MonoAlg3D_C). Ten folders are provided with the name AtrialAnatomyX (X being an integer from 1 to 10). Inside each folder there are many subfolders. The baseline atrial mesh is inside a folder called Baseline, which includes:
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Geometry with atrial region tags: atria_AA_X.alg
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Fibers for the corresponding anatomy: atria_AA_X.fibers
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Stimulation files for stimulating the sinoatrial node (SAN) and left pulmonary veins (lPV): atria_AA_X_SAN.pts and atria_AA_X_lPV.pts
These atrial anatomies might be presented with absence of low voltage areas (FB_0) or with 15% low voltage areas in the right and left atrium (FB_1). Therefore, the actual names that can be found inside the Baseline folder are:
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atria_AA_X_FB_0.alg
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atria_AA_X_FB_1.alg
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atria_AA_X_FB_0.fibers
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atria_AA_X_FB_1.fibers
Inside the Baseline folder there is an additional file with the suffix (*SV_AF.txt). This file includes the State Variables (or initial conditions) needed to impose AF in the tissue for each geometry:
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atria_AA_1_SV_AF.txt
Apart from the Baseline subfolder, each AtrialAnatomyX folder has 9 additional subfolders. These correspond to 9 catheter ablation treatments:
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Ablation of low voltage areas (LVA)
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Marshal-Plan
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Left atrial anterior mitral line (MiLine)
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MiLine and cavo-tricuspid isthmus block (MiLine+CTI)
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MiLine+CTI + right atrial MiLine (MiLine+CTI+MiLineRA)
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Pulmonary vein isolation (PVI)
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Posterior wall isolation (PWI)
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PWI plus mitral isthmus block (PWI+MI)
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PWI+MI+CTI
These treatment subfolders include the mesh file (.alg), fibers file (.fibers) and the initial conditions file to impose AF (*SV_AF.txt) considering the ablation lesion already in the tissue. For example, for PVI the files look like:
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atria_AA_1_FB_0_PVI.alg (without low voltage areas)
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atria_AA_1_FB_1_PVI.alg (with low voltage areas)
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atria_AA_1_FB_0_PVI.fibers
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atria_AA_1_FB_1_PVI.fibers
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atria_AA_1_SV_AF_PVI.txt
Additional to the atrial anatomies, configuration files for running simulations are provided in the folder ConfigurationFiles.
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Each configuration file corresponds to a different virtual patient (VirtPat) and has the following name:
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VirtPat_EP_X_AA_Y_FB_Z_Treatment.ini
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EP_X (electrophysiology): X is an integer ranging from 1 to 40. Different electrophysiology is reflected in the different scaling factors used for the maximal conductance of ionic currents.
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AA_Y (Atrial anatomy). Y is an integer ranging from 1 to 10. Call to the atrial meshes described above.
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FB_Z (Fibrosis). Z is a boolean value, either 0 (no LVA) or 1 (15% LVA).
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Treatment: This is a string that needs to be replaced by the treatment names described above: PVI, PWI, MiLine, etc.
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Files
Simulations_UOX.zip
Files
(9.2 GB)
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