Genetic implications in patients with NAFLD

MISIAK, Jakub, KĘPCZYK, Martyna, KWAŚNIEWSKA, Oliwia, URBAŚ, Michał, OJDANA, Miłosz, DEMIANENKO, Yehor, CZEKAJ, Oliwia, KOŚCIOŁEK, Aleksandra, KOŚCIOŁEK, Dawid and SUROWIECKA, Kaja. Genetic implications in patients with NAFLD. Journal of Education, Health and Sport. 2024;53:198-214. eISSN 2391-8306. https://dx.doi.org/10.12775/JEHS.2024.53.015

https://apcz.umk.pl/JEHS/article/view/47859

https://zenodo.org/records/10532440

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of 05.01.2024 No. 32318. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical culture sciences (Field of medical and health sciences); Health Sciences (Field of medical and health sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 05.01.2024 Lp. 32318. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe:  Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2024;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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Received: 06.01.2024. Revised: 17.01.2024. Accepted: 17.01.2024. Published: 19.01.2024.

Genetic implications in patients with NAFLD

Jakub Misiak, Department of Pathology, Chair of Oncology, Medical University of Lodz, ul. Pabianicka 62, 93-513 Lodz, Poland

https://orcid.org/0009-0003-1176-3994, misiakj98@gmail.com   

Martyna Kępczyk, Medical University of Lodz, al. Tadeusza Kosciuszki 4, 90-419 Lodz, Poland

https://orcid.org/0009-0004-3556-6925,  martyna.kepczyk@wp.pl

Oliwia Kwaśniewska, Norbert Barlicki Memorial Teaching Hospital No.1 of the Medical University of Lodz, ul. Dr. Stefana Kopcinskiego 22, 90-153 Lodz, Poland

https://orcid.org/0000-0002-7361-552X, oliwiakwasniewska1998@gmail.com

Michał Urbaś,  Stefan Zeromski Specialist Hospital, ul. Osiedle Na Skarpie 66, 31-913 Krakow, Poland

https://orcid.org/0009-0005-2762-4723, Michal.urbas97@gmail.com 

Miłosz Ojdana, Military Medical Academy Memorial Teaching Hospital – Central Veterans’ Hospital, ul. Zeromskiego 113, 90-549 Lodz, Poland

https://orcid.org/0009-0002-4901-7252,   miloszojdana77@gmail.com

Yehor Demianenko, Independent Public Health Care Facility of the Ministry of Interior and Administration in Lodz, ul. Polnocna 42, 91-425 Lodz, Poland

https://orcid.org/0000-0001-5791-0492,  yehor.demianenko@gmail.com

Oliwia Czekaj, Rydygier Clinical Hospital in Cracow, Osiedle Zlotej Jesieni 1, 31-826 Krakow, Poland

https://orcid.org/0009-0001-5705-0856, oliwia.czekaj@gmail.com

Aleksandra Kościołek, Medical University of Lodz, al. Tadeusza Kosciuszki 4, 90-419 Lodz, Poland

https://orcid.org/0009-0000-1307-8438, a.kosciolekk@gmail.com

Dawid Kościołek, Medical University of Lodz, al. Tadeusza Kosciuszki 4, 90-419 Lodz Poland

https://orcid.org/0009-0001-7946-753X, d.d.kosciolek@gmail.com

Kaja Surowiecka, Student Research Club of Orthopedics and Traumatology, Medical University of Lublin, ul. Aleje Raclawickie 1, 20-059 Lublin, Poland

https://orcid.org/0009-0009-7951-5448,  kajasuro@gmail.com

Corresponding author:

Jakub Misiak

Department of Pathology, Chair of Oncology, Medical University of Lodz, ul. Pabianicka 62, 93-513 Lodz, Poland

misiakj98@gmail.com   

Abstract

Introduction and purpose:

Non-alcoholic fatty liver disease's growing prevalence and the complications it brings constitutes a serious problem nowadays. According to this, better understanding of mechanisms laying on the ground of its pathogenesis is a crucial factor to better understand this disease and develop interventions to counter its effects. Genetic relationships with NAFLD are known and they show great variation of mechanisms underlying their impact on subjects' metabolic state. Due to this fact the assumption that it is worth collecting these connections in one place was made, so that it is easier to navigate in them. Mostly studies refer to rodents trials, we focused on studies referred to people with NAFLD diagnosis.

Material and method: 

The literature was scrutinised in the Google Scholar database,  in the Pubmed database with the use of following keywords: “genetics”, “genes”, “non-alcoholic fatty liver disease”, “NAFLD”, “non-alcoholic steatohepatitis”, “NASH”.

Results:

NAFLD as a metabolic disease has many links with metabolic pathways encoded by various genes. When it comes to genetic factors, we can specify gene expression single nucleotide polymorphisms (SNP) and genes methylation. All of these aspects affect activity of coded proteins and what follows this is its impact on human metabolism.  These factors have been studied in the work of other researchers.

Conclusions:

 Non-alcoholic fatty liver disease's growing prevalence and the complications it brings constitutes a serious problem nowadays. Genetic relationships with NAFLD are known and they show great variation of mechanisms underlying their impact on subjects' metabolic state.

 Keywords: non-alcoholic fatty liver disease; genetics; steatosis