The impact of the ketogenic diet on the health of patients with Alzheimer's disease

SAMBORSKA, Julia, WIĘCKOWIAK, Paweł, STELMASZAK, Karina, STENCEL, Katarzyna, OGIEGŁO-KOWALCZYK, Aleksandra, WOJTASIK, Monika, GŁODZIK, Michał, MIŚKIEWICZ, Marek, ŻAK, Katarzyna and ŁĘCKA, Martyna. The impact of the ketogenic diet on the health of patients with Alzheimer’s disease. Journal of Education, Health and Sport. 2024;52:98-110. eISSN 2391-8306. https://dx.doi.org/10.12775/JEHS.2024.52.007

https://apcz.umk.pl/JEHS/article/view/47775

https://zenodo.org/records/10493014

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of 05.01.2024 No. 32318. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical culture sciences (Field of medical and health sciences); Health Sciences (Field of medical and health sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 05.01.2024 Lp. 32318. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe:  Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2024;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 02.01.2024. Revised: 06.01.2024. Accepted: 09.01.2024. Published: 11.01.2024.

THE IMPACT OF THE KETOGENIC DIET ON THE HEALTH OF PATIENTS WITH ALZHEIMER’S DISEASE

Julia Samborska

SPZOZ Okręgowy Szpital Kolejowy w Katowicach

julia.samborska.med@gmail.com

https://orcid.org/0009-0001-2157-7015

Paweł Więckowiak

Śląski Uniwersytet Medyczny w Katowicach

pawew36@gmail.com

https://orcid.org/0009-0004-6610-1792

Karina Stelmaszak

SPZOZ Okręgowy Szpital Kolejowy w Katowicach

stelmaszak1259@gmail.com

https://orcid.org/0009-0006-3877-2753

Katarzyna Stencel

Specjalistyczny Zakład Opieki Zdrowotnej "MULTIMED" Sp. zoo

katarzynastencel96@gmail.com

https://orcid.org/0009-0006-9574-9277

Aleksandra Ogiegło-Kowalczyk

SPZOZ Okręgowy Szpital Kolejowy w Katowicach

aleksandra.ogieglo@gmail.com

https://orcid.org/0009-0008-8773-7123

Monika Wojtasik

Przychodnia Wielospecjalistyczna w Mikołowie

monika.wojtasik95@gmail.com

https://orcid.org/0009-0008-6723-3841

Michał Głodzik

Przychodnia Bracka Bielszowice, Ruda Śląska

glodzikmichal@gmail.com

https://orcid.org/0009-0009-4751-1784

Marek Miśkiewicz

Wojewódzki Szpital Podkarpacki im.Jana Pawła II w Krośnie

miskiewiczkeram@gmail.com

https://orcid.org/0000-0002-3691-343X

Katarzyna Żak

Uniwersyteckie  Centrum Kliniczne w Gdańsku

lek.katarzyna.zak@gmail.com

https://orcid.org/0009-0000-7056-1960

Martyna Łęcka

Szpital Murcki Sp z o.o. Katowice, Sokołowskiego 2, 40-749 Katowice

martyna.lecka@gmail.com

https://orcid.org/0009-0007-1473-8400

ABSTRACT:

INTRODUCTION:

Diet is an integral element of every individual's health. Its impact on the functioning of the human body has fascinated scientists for years. One of the diets that alters the mechanism of the body's functioning is the ketogenic diet. The impact of the ketogenic diet on various disorders is still under investigation. It is known to have shown numerous benefits in reducing epileptic seizures, but its impact on other neurological disorders is less known. In this literature review, the efficacy of ketogenic therapies was assessed in Alzheimer's disease.

AIM OF STUDY:

Review of the current literature (since 2018) on the effects of implementing a ketogenic diet in patients with Alzheimer's disease.

MATERIALS AND METHODS:

The review was based on data gathered from the PubMed database using the keywords: 'ketogenic diet in Alzheimer’s disease,' 'ketogenic therapies Alzheimer disease,' and 'ketogenic diet in neurological disease’.

SUMMARY:

The ketogenic diet enhances the daily functioning of Alzheimer's patients. It significantly improves their cognitive functions, and changes in brain blood flow are visible in imaging studies. The ketogenic diet also positively modulates the gut microbiome in Alzheimer's patients. It represents a promising option in combating cognitive symptoms of Alzheimer's disease.

KEY WORDS: Health; Diet; Ketogenic diet; Alzheimer’s disease; Diet in neurological diseases; Nutrition; Ketone bodies