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Published October 17, 2023 | Version v1
Dataset Open

Secondary Graft Loss After Third-party "Off-The-Shelf" Antigen-Specific T cell Infusion

Creators

  • 1. Children's National Hospital
  • 2. St. Jude Children's Research Hospital
  • 3. Children's Hospital Atlanta
  • 4. National Cancer Institute
  • 5. University of Utah Health Huntsman Cancer Institute

Description

Here, we describe a severe adverse event of virus-specific T cell (VST therapy) in an infant with severe combined immunodeficiency who received VSTs for treatment of CMV viremia post-transplant and developed secondary graft rejection at 1-month post-VST infusion associated with the expansion of VST donor-derived T cells. Deposited here are the bulk repertoire and single-cell gene expression and TCR  data from the study.

bulk_rep.zip contains tables of alpha/beta TCR sequences for post-infusion, VST donor, and VST product samples, and samples stimulated with neoepitope peptides. 

VST_agg_wTCR_SS.rds is an R Data Serialization file containing a Seurat object of the processed 10X single-cell gene expression and TCR profiling for the post-infusion, VST donor, and VST product samples. TCR information is stored in the meta.data slot.

 

Files

bulk_tcr.zip

Files (113.5 MB)

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md5:a80e1467975902da6784dcef6400b29c
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md5:e22ed4740496b26f56ccd9618ebdb4c2
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