Nutrients deficiencies in patients with autism spectrum disorder, role of folic acid and vitamin D3 - review of literature

MAŁACHOWSKA, Dominika, ŚWIERCZ, Aleksandra, ŻUREK, Urszula, TOŁWIŃSKI, Ignacy, KĘDZIERSKA, Zofia, ANTKOWIAK, Klaudia, DADAS, Klaudia, CIECIERSKI-KOŹLAREK, Hubert and SHVED, Kateryna. Nutrients deficiencies in patients with autism spectrum disorder, role of folic acid and vitamin D3 - review of literature. Journal of Education, Health and Sport. 2023;39(1):105-117. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.39.01.009

https://apcz.umk.pl/JEHS/article/view/44954

https://zenodo.org/record/8212741

 

 

 

 

 

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of 17.07.2023 No. 32318. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 17.07.2023 Lp. 32318. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2023;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 07.07.2023. Revised:30.07.2023. Accepted: 31.07.2023. Published: 08.08.2023.

 

 

 

 

 

 

Nutrients deficiencies in patients with autism spectrum disorder, role of folic acid and vitamin D3 - review of literature

Authors:

 

Dominika Małachowska

Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland

ORCiD: 0009-0008-6305-7959

e-mail: dominika1.malachowska@gmail.com

 

Aleksandra Świercz

Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland

ORCiD: 0009-0007-1535-1590

e-mail: aleksandra.swiercz1996@gmail.com

 

Urszula Żurek

Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland

ORCiD: 0009-0008-3482-5381

e-mail: ula.zurek@gmail.com

 

Ignacy Tołwiński

Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland

ORCiD: 0000-0003-1362-6734

e-mail: ignacyt233@gmail.com

 

 

Zofia Kędzierska

Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland

ORCiD: 0000-0002-4181-4719

e-mail: zo.kedzierska@gmail.com

 

Klaudia Antkowiak

Szpital Średzki Serca Jezusowego z.o.o ul. Żwirki i Wigury 10, 63-000 Środa Wielkopolska, Poland

ORCiD: 0009-0008-3421-2200

e-mail: klaudia.antkowiak2021@gmail.com

 

Klaudia Dadas

Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland

ORCiD: 0009-0007-3352-9807

e-mail: klaudia.w.2703@gmail.com

 

Hubert Ciecierski-Koźlarek

Wojewódzki Szpital Specjalistyczny w Olsztynie, ul. Żołnierska 18, 10-561 Olsztyn, Poland

ORCiD: 0009-0009-4062-6888

e-mail: hubertciecierski@icloud.com

 

Kateryna Shved

Wielospecjalistyczny Szpital Miejski im. Józefa Strusia, ul. Szwajcarska 3, 61-285 Poznań, Poland

ORCiD: 0009-0002-3773-7025

e-mail: katey.shved@gmail.com

 

Abstract

Introduction and purpose:

This article will discuss the relationship between nutrition deficiency, focusing on folic acid and vitamin D3 and autism spectrum disorder (ASD). Research suggests that nutrient deficiencies play a role in the development and progression of autism. This article will investigate causes of nutrient deficiencies in ASD, like dietary constraints, food choice, and environment exposure, and their impact on ASD and related symptoms. The purpose of this article is to provide an overview of the research examining the relationship between folic acid and vitamin d3 supplementation and autism.

Materials and methods:

A broad search was conducted using the PubMed database in order to identify relevant studies published between 2010-2020 using keywords such as “folic acid”, “folinic acid”, "vitamin d3", "autism spectrum disorder".

A brief description of the current state of knowledge:

 

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that in recent years has been increasingly diagnosed among children. Only between 2016 and 2014 measured prevalence in the United States has increased by 10%. [1] The exact etiology of ASD in not known. In this review we will examine a role of folic acid and vitamin D3. Research suggests that folic acid supplements can help improve verbal skills in people with ASD. Research also shows decreased levels of vitamin d3 in ASD patients. Clinical trials involving vitamin d3 present inconclusive data but lean towards positive impact of supplementation. Both folic acid and vitamin d3 supplementation is safe. Dietary changes and oral supplementation may be beneficial for patients.

Conclusions:

Studies with larger participant numbers should be done to prove the significance of folic acid and vitamin D3 supplementation as it shows potential in being a safe and not expensive complementary therapeutic option.

 

Keywords: autism spectrum disorder; vitamin D3; folic acid; folinic acid; verbal communication; dietary intervention,