Contemporary treatment options for male hypogonadism

SOJKA, Paweł, POPIOŁEK, Joanna, SZCZERBA, Jakub, POKORA, Szymon, STEFANOWICZ, Agata, POKŁADNIK, Dominika, JELEŃ, Katarzyna, POKORA, Karolina, PODSIEDLIK, Adam and POLOCZEK, Alicja. Contemporary treatment options for male hypogonadism. Journal of Education, Health and Sport. 2023;25(1):107-119. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.25.01.010

https://apcz.umk.pl/JEHS/article/view/44763

https://zenodo.org/record/8173576

 

 

 

 

 

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2023;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

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The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 27.06.2023. Revised: 20.07.2023. Accepted: 20.07.2023. Published: 25.07.2023.

 

 

 

 

 

 

 

Contemporary treatment options for male hypogonadism

 

 

1.Paweł Sojka

pawel.sojka@sum.edu.pl

Śląski Uniwersytet Medyczny w Katowicach

https://orcid.org/0000-0002-1065-6316

 

2.Joanna Popiołek

popiolek.joanna@o2.pl

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie

https://orcid.org/0009-0003-0660-8463

 

3.Jakub Szczerba

JAKUB.SZCZERBA@o2.pl

Szpital Zakonu Bonifratrów pw. Aniołów Stróżów w Katowicach

https://orcid.org/0009-0001-3872-3488

 

4.Szymon Pokora

szymonpokora@interia.pl

Wojewódzki Szpital Specjalistyczny nr 5 im. św. Barbary w Sosnowcu Centrum urazowe

https://orcid.org/0000-0002-1250-6282

 

5.Agata Stefanowicz

agata.stefanowicz@interia.pl

Szpital Zakonu Bonifratrów pw. Aniołów Stróżów w Katowicach

https://orcid.org/0009-0009-0702-579X

 

6.Dominika Pokładnik

dominika_med@op.pl

Górnośląskie Centrum Medyczne im. prof. Leszka Gieca Śląskiego Uniwersytetu Medycznego w Katowicach

https://orcid.org/0009-0001-9132-7425

 

7.Katarzyna Jeleń

katarzyna.jelen@onet.pl

Szpital Zakonu Bonifratrów pw. Aniołów Stróżów w Katowicach  

https://orcid.org/0009-0003-1166-526X

 

8.Karolina Pokora

koziel.karolina778@gmail.com

Szpital Zakonu Bonifratrów pw. Aniołów Stróżów w Katowicach

https://orcid.org/0009-0008-8214-4476

 

9.Adam Podsiedlik

adam.podsiedlik27@gmail.com

Wojewódzki Szpital Specjalistyczny Megrez Sp. z o.o.

https://orcid.org/0009-0004-2735-0905

10.Alicja Poloczek

alicja.poloczek7@gmail.com

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie

https://orcid.org/0009-0004-6539-5290

 

Keywords: Hypogonadism, testosterone, androgens, therapy, andrology, sexology

 

 

Abstract
Introduction

Male hypogonadism is a disease in which testicular function is impaired. Its symptoms are due to testosterone deficiency and most of them show low specificity. These include reduced libido, erectile dysfunction and mood disorders, among others. The biochemical indicator of hypogonadism is a testosterone concentration below 350 ng/ml (12nmol/L), according to the European Association of Urology (EAU). The increased incidence of hypogonadism is associated with aging and the presence of comorbidities such as type II diabetes and obesity. Men with testosterone deficiency have an increased risk of cardiovascular disease and premature death.

Goals

Summary of current reports on the diagnosis and treatment of hypogonadism. An overview of the advantages and disadvantages of the different types of formulations used in testosterone replacement therapy.

Methods
 Review of literature available in PubMed and Google Scholar databases.

Conclusions

The medical interview, physical examination and ancillary tests help to classify hypogonadism appropriately. Measuring the concentration of gonadotropins, helps diversify primary from secondary hypogonadism. Testosterone replacement therapy (TRT) uses formulations that have varying release profiles, route of administration and drug formulation. The choice of testosterone product should involve age, lifestyle, and individual preferences of the patient.