Current state of knowledge on the use of cannabidiol (CBD) in various medical conditions

LUBCZYŃSKA, Zuzanna, PRZERADZKI, Jakub, BORYCKA, Aleksandra, KOTULSKA, Maria, LICHMAN, Martyna, JĘDRZEJEWSKA, Barbara, LASKUS, Paulina, POTOCKA, Zofia, SIEKIERKO, Nikola & ŻOŁNIEREK, Maja. Current state of knowledge on the use of cannabidiol (CBD) in various medical conditions. Journal of Education, Health and Sport. 2023;38(1):50-63. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.38.01.004

https://apcz.umk.pl/JEHS/article/view/43910

https://zenodo.org/record/8012236

 

 

 

 

 

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2023;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 09.05.2023. Revised: 05.06.2023. Accepted: 05.06.2023. Published: 07.06.2023.

 

 

 

 

 

Current state of knowledge on the use of cannabidiol (CBD) in various medical conditions

 

Zuzanna Lubczyńska

Grochowski Hospital im. dr med. Rafała Masztaka Grenadierów 51/59 St., 04-073 Warsaw, Poland

 https://orcid.org/0000-0002-4860-2508

Jakub Przeradzki

Specialist Hospital in Międzylesie Bursztynowa 2 St., 04-749 Warsaw, Poland

 https://orcid.org/0009-0001-2941-6670

Aleksandra Borycka

Central Clinical Hospital of the Ministry of Interior and Administration in Warsaw Wołoska 137 St., 02-507 Warsaw, Poland

 https://orcid.org/0009-0002-5589-1827

Maria Kotulska

Central Clinical Hospital of the Ministry of Interior and Administration in Warsaw Wołoska 137 St., 02-507 Warsaw, Poland

 https://orcid.org/0009-0003-9111-6745

Martyna Lichman

Szpital Chirurgii Urazowej św. Anny Barska 16/20 St., 02-315 Warsaw, Poland

 https://orcid.org/0009-0007-5473-4973

Barbara Jędrzejewska

Powiatowe Centrum Zdrowia w Otwocku, Stefana Batorego 44 St., 05-400 Otwock, Poland

 https://orcid.org/0009-0002-2153-4311

Paulina Laskus

Specialist Hospital in Międzylesie Bursztynowa 2 St., 04-749 Warsaw, Poland

 https://orcid.org/0009-0006-6882-8797

Zofia Potocka

Central Clinical Hospital of the Ministry of Interior and Administration in Warsaw Wołoska 137 St., 02-507 Warsaw, Poland

 https://orcid.org/0009-0008-7738-2795

Nikola Siekierko

Szpital Praski p.w. Przemienienia Pańskiego Aleja Solidarności 67, 03-401 Warsaw, Poland

 https://orcid.org/0000-0002-1113-7112

Maja Żołnierek

Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. św. Jana Pawła II w Grodzisku Mazowieckim Daleka 11 St., 05-825 Grodzisk Mazowiecki, Poland

 https://orcid.org/0000-0001-9030-7505

 

Keywords: cannabidiol (CBD), Anxiety, Epilepsy, Pain, cannabis

 

 

Abstract

INTRODUCTION AND PURPOSE

Cannabis sativa contains hundreds of compounds, referred to as cannabinoids. Two most prevalent are delta-9-tetrahydrocannabinol and cannabidiol (CBD). CBD is non-psychoactive substance that has recently gained attention in lay press and in medical research. Aim of this study is to review evidence-based data on safety, effectiveness and applicability of CBD in various medical conditions in order to provide healthcare professionals with information that may be useful in their practice.

MATERIALS AND METHODS

In April 2023, PubMed and Google Scholar databases were searched for studies that included phrases “CBD” or “cannabidiol”, and related phrases. In the review, only studies that used well-established research methods were included.

RESULTS

CBD is an effective novel treatment option in Lennox–Gastaut syndrome, tuberous sclerosis complex and Dravet syndrome. Data supporting CBD’s applicability in anxiety, Parkinson’s Disease, schizophrenia, insomnia, pain, autoimmune diseases, osteoporosis and as an anti-aging agent is promising, but more research on bigger groups of patients is needed to establish its role in modern medicine.

CONCLUSIONS

The use of CBD is associated with risks of variable dosage, contamination and adulteration. At present, there is a need of more research to establish effective and safe doses of CBD. Clinicians need to monitor new data from ongoing CBD trials, but at present there is no hard evidence supporting effectiveness of CBD in various medical conditions, apart from epilepsy.