Comparative study of the effects of fresh and canned Naftussya bioactive water on neuro-endocrine-immune complex and metabolism in chronic pyelonephritis patients

POPOVYCH, Andriy, POPOVYCH, Dariya, RUZHYLO, Sofiya, ZAKALYAK, Nataliya, ZUKOW, Xawery, SHYPYTIAK, Yevstakhii & FIL, Vitalij. Comparative study of the effects of fresh and canned Naftussya bioactive water on neuro-endocrine-immune complex and metabolism in chronic pyelonephritis patients. Journal of Education, Health and Sport. 2023;17(1):11-20. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.17.01.001

https://apcz.umk.pl/JEHS/article/view/43277

https://zenodo.org/record/7767177

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2023;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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Received: 09.02.2023. Revised: 14.03.2023. Accepted: 22.03.2023. Published: 24.03.2023.

Comparative study of the effects of fresh and canned Naftussya bioactive water on neuro-endocrine-immune complex and metabolism in chronic pyelonephritis patients

Andriy I. Popovych^1,2, Dariya V. Popovych³, Sofiya V. Ruzhylo⁴, Nataliya R. Zakalyak⁴,

Xawery Zukow⁵, Yevstakhii Shypytiak⁴, Vitalij M. Fil⁴

¹SE Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, Ukraine

²Scientific group of Balneology of Hotel&Spa Complex “Karpaty”, Truskavets’, Ukraine andriypopovych711@gmail.com

³IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine darakoz@yahoo.com

⁴Ivan Franko State Pedagogical University, Drohobych, Ukraine

fillvitalij@gmail.com  doctor-0701@ukr.net  natalyzak69@gmail.com yevstakhiishypytiak@gmail.com

⁵Medical University of Bialystok, Bialystok, Poland xaweryzukow@gmail.com

Background. There are several patented methods of preservation of medicinal waters of the Naftussya type. The authors of the patents as evidence of the correctness of the methods cite the facts of preservation of the ability of canned water to enhance motility rat’s v. portae in vitro and/or increase diuresis. However, such tests are not attributive. The most characteristic manifestation of the biological activity of Naftussya water is the stimulation of phagocytosis through the mediation of the nervous and endocrine systems. Another "Method of preservation of hydrogen sulfide mineral waters" was recently patented. The purpose of this study is to compare the impact of fresh and canned by this method Naftussya water on its targets in patients with chronic pyelonephritis. Materials and Methods. The object of clinical-physiological observation were residents of the city of Truskavets’ (21 men aged 24-67 years and 8 women 33-76 years) with chronic pyelonephritis in remission. The subject of the study were the phagocytic function of neutrophils, excretory function of kidneys, leukocyturia and bacteriuria levels, components of microbiota of feces as well as HRV and endocrine parameters. Results. Weekly use of fresh Naftussya water causes an increase in the reduced content of probiotics in the microbiota and a decrease in the increased content of conditionally pathogenic microflora, which is accompanied by an increase in reduced bactericidal capacity of neutrophils against both E. coli and Staph. aureus, normal diuresis, phosphaturia, magnesiumuria, ureauria while reduction of bacteriuria and leveling of leukocyturia as well as decrease in concentration of uric acid in urine and creatinine and cholesterol in plasma. Favorable changes in neuro-endocrine regulation were revealed. The beneficial effect on the listed parameters of canned Naftussya water is less pronounced, but the differences are statistically insignificant. Conclusion. The obtained results confirm the effectiveness of the Dovzhenko^© method for Naftusya water conservation and provide grounds for continuing research into the effects of canned Naftusya water on the body of urological patients.

Keywords: Naftussya bioactive water, Dovzhenko^© conservation method, chronic pyelonephritis, urinary syndrome, microbiota, phagocytosis, diuresis, saluresis, HRV, adaptation hormones.