FORMULATION AND EVALUATION OF SIMVASTATIN MATRIX TABLETS

Formulation and evaluation of the sustained release tablets of the Simvastatin.  The before going to formulate the tablets the preformulation studies are carried out such as FTIR,calibration,organoleptic characters. The formulation is developed by using different types of the super disintegrates such as the hpmc and xanthin gum in different trails. The pre compression parameters such as angle of repose ,bulk density, true density, compressability index, these are found to be within the limits. The oral dispersible tablets of Nizatidine tablets are prepared by the direct compression method. The talc used as glidant and lactose used as lubricant mcc used as filler. The after development of oral dispersible tablets are undergo for evaluation parameters. Such as weight variation, thickness, friability, drug content, disintegration, and In vitro dissolution studies. They all are found in within range of limits. The in vitro drug release studies carried out by USP-II apparatus. The buffer medium 6.8 . The optimised formulation undergo for stability studies for 3 months .In stability studies the drug content and drug release studies carried out. These no degradation takes place in the drug content and drug release studies.

Key words: Formulation, Evaluation of Simvastatin, matrix tablets