Sexual dimorphism in relationships between of plasma urea and some psycho-neuro-endocrine parameters

Bombushkar, Igor, Anchev, Anatoliy, Żukow, Xawery & Popovych, Igor. Sexual dimorphism in relationships between of plasma urea and some psycho-neuro-endocrine parameters. Journal of Education, Health and Sport. 2022;12(8):1198-1205. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.08.104

https://apcz.umk.pl/JEHS/article/view/41218

https://zenodo.org/record/7410935

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2022;

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Received: 02.08.2022. Revised: 07.08.2022. Accepted: 26.08.2022.

Sexual dimorphism in relationships between of plasma urea and some psycho-neuro-endocrine parameters

Igor S. Bombushkar^1,2, Anatoliy S. Anchev², Xawery Żukow³, Igor L. Popovych⁴

¹Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, Ukraine

²Donets’kian National Medical University, Kropyvnyts’kyi, Ukraine

bombuchkar@gmail.com

³Medical University of Bialystok, Bialystok, Poland xaweryzukow@gmail.com

⁴OO Bohomolets’ Institute of Physiology of NAS of Ukraine, Kyїv, Ukraine i.popovych@biph.kiev.ua

Summary

Background. Earlier we found a strong urato-neural relationships in both men and women. Moreover, in women, the factor structure of the neural root is almost completely different from that in men. In addition, significant differences were found between the profiles of urato-neural correlations of women of reproductive age and postmenopausal women. The purpose of this study is to analyze the relationships between the plasma urea level and some psycho-neuro-endocrine parameters in the same cohort. Materials and Methods. The object of observation were almost healthy volunteers: 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). In basal conditions we determined plasma levels of urea and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By building regression models with stepwise exclusion, it was found that in men plasma urea positively determines (R²=0,499) the level of circulating catecholamines and power spectrum density (PSD) of δ-, θ- and β-rhythms in different loci. In postmenopausal women, urea downregulates the amplitude and PSD of δ-rhythm in different loci, instead, it upregulates the PSD of α-rhythm in T5 locus, entropy of EEG in 2 loci and vagal tone. The degree of determination of neural parameters is 71,6%. In women of reproductive age the degree of determination of neural parameters is similar (69,9%), but the factor structure of the model is completely different. Urea upregulates the PSD of β-rhythm in F7 locus while downregulates the levels of reactive anxiety, vagal tone, entropy of EEG in 3 loci and P4-θ PSD as well as causes left lateralization of θ- and α-rhythms. Conclusion. Plasma urea has a modulating effect on EEG&HRV parameters, as well as reactive anxiety, but this effect is significantly different in men and women of different ages.

Keywords: plasma urea, cortisol, testosterone, aldosterone, triiodothyronine, calcitonin, ongoing EEG, HRV, anxiety, men, women.