Congenital Anomalies in Neonates Conceived by in Vitro Fertilization; Hospital Based Study

Congenital Anomalies in Neonates Conceived by in Vitro Fertilization; Hospital Based Study
Abed S.M,  Albermany S.A, Alnassrawi  L.A, Baythoon M.B

Summary
Background: The percentage of children born after in vitro fertilization will continue to increase due to demographic changes such as increasing maternal age and new developments in assisted reproduction techniques. In vitro fertilization conceptions may carry an increased risk of congenital malformations.
Objective: To measure the rate of congenital anomaly for neonates born by In vitro fertilization in comparison to the rate of  congenital anomalies in neonates born by natural conception in Baghdad Teaching Hospital.
Patients and methods: This study is a case control study conducted in Neonatal Intensive Care Unit of Baghdad Teaching Hospital in medical city through the period from 1st of May to 30th of November,2018 on in vitro fertilization births. The congenital anomaly rate in the general population was derived from routine register of congenital anomalies in department of statistics of Baghdad teaching hospital ,where as the rates within in vitro fertilization population are derived from detailed examination and follow up.
Results: The rate of congenital anomaly among neonates born spontaneously in Baghdad Teaching Hospital was 1.2%, while rate of congenital anomaly among neonates born by in vitro fertilization in Baghdad Teaching Hospital was 26% commonly central nervous system where five cases detected. There was a high significant association between multiple pregnancies and in vitro fertilization neonate and a high significant association between positive consanguinity and in vitro fertilization neonates with anomalies.
Conclusions: The rate of congenital anomalies for infants born by in vitro fertilization is higher than rate of congenital anomalies for infants born by spontaneous birth in Baghdad Teaching hospital.
Keywords: In vitro fertilization, Congenital anomaly, Consanguinity

DOI: 10.5281/zenodo.7014014