Peculiarities of modulating effects of "Myroslava" and "Khrystyna" mineral waters on neuroendocrine-immune complex and metabolism in patients of Truskavets' spa

Popovych Igor L., Gozhenko Anatoliy I., Hrytsak Myroslava V., Popovych Dariya V., Badiuk Nataliya S., Zukow Walery. Peculiarities of modulating effects of “Myroslava” and “Khrystyna” mineral waters on neuroendocrine-immune complex and metabolism in patients of Truskavets’ spa. Journal of Education, Health and Sport. 2022;12(3):53-66. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.03.005

https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.03.005

https://zenodo.org/record/6350608

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2022;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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Received: 20.02.2022. Revised: 28.02.2022. Accepted: 13.03.2022.

Peculiarities of modulating effects of “Myroslava” and “Khrystyna” mineral waters on neuroendocrine-immune complex and metabolism in patients of Truskavets’ spa

Igor L. Popovych^1,2, Anatoliy I. Gozhenko^1,4, Myroslava V. Hrytsak^1,2,

Dariya V. Popovych³, Nataliya S. Badiuk^1,4, Walery Zukow⁵

¹SE Ukrainian Research Institute of Medicine of Transport, Odesa badiuk_ns@ukr.net

²Scientific group of Balneology of Hotel&Spa Complex "Karpaty", Truskavets’, Ukraine      hrytsak.myroslava@gmail.com  ira_barschyk@ukr.net

³IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine  darakoz@yahoo.com

⁴International Medical University, Odesa, Ukraine

⁵Nicolaus Copernicus University, Torun, Poland   w.zukow@wp.pl

Abstract

Background. Earlier we found effects on the neuroendocrine-immune complex and metabolism, which are common to the mineral waters "Myroslava" and "Khrystyna", instead different from the effects of Naftussya water. The purpose of this article is to find the specific effects of these waters. Materials and Methods. The object of clinical-physiological observation were 22 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission in the Truskavets’ spa. The examination was performed twice, before and after a 7-10-day course of balneotherapy. Half of the patients received bioactive water Naftussya and sulfate-chloride sodium-magnesium mineral water "Myroslava" (M 5 g/L), and the other half - Naftussya and "Khrystyna" (M 10 g/L). The subject of the study were the parameters of the neuroendocrine-immune complex, microbiota, cholekinetics and metabolism. Results. Screening revealed specific changes in 37 parameters grouped into 5 patterns. The first pattern combines 11 parameters that decrease under the influence of "Myroslava" water (Myr), while increase under the influence of "Khrystyna" water (Khr). For the other 7 parameters of the second pattern, Myr acts similarly, while Khr is ineffective. Both mineral waters have a stimulating effect on 8 parameters, while Myr is inferior to Khr. Myr has a upregulating effect on 9 parameters of the fourth pattern, while Khr has a downregulating effect. Finally, sodium excretion and leukocyturia are reduced under the influence of both waters, but to a greater extent under the influence of Khr. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have both common and specific favorable modulating neuroendocrine, metabolic and immune effects on patients with chronic cholecystitis and pyelonephritis.

Keywords: sulfate-chloride sodium-magnesium drinking mineral waters, Truskavets’ spa, EEG, HRV, hormones, metabolism, immunity.