What are the newest outcomes about Legg-Calve-Perthes disease etiology after 110 years over its discovering? – literature review

Węgrzyniak Agata, Wokurka Wojciech, Dudek Iga, Piech Piotr. What are the newest outcomes about Legg-Calve-Perthes disease etiology after 110 years over its discovering? – literature review. Journal of Education, Health and Sport. 2021;11(9):396-400. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.09.050

https://apcz.umk.pl/JEHS/article/view/JEHS.2021.11.09.050

https://zenodo.org/record/5519997

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Received: 15.09.2021. Revised: 21.09.2021. Accepted: 21.09.2021.

What are the newest outcomes about Legg-Calve-Perthes disease etiology after 110 years over its discovering? – literature review

Agata Węgrzyniak¹,Wojciech Wokurka¹, Iga Dudek²

Supervisor: PhD Piotr Piech^3,4

Afiliacja:

¹ Human Anatomy Research Group, Department of Human Anatomy, Medical University of Lublin

² Student Research Group at the Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin

³ Department of Human Anatomy, Medical University of Lublin

⁴ Department of Orthopedics and Traumatology, Medical University of Lublin

ORCID ID:

Agata Węgrzyniak: https://orcid.org/0000-0001-8638-0013; agataw97@gmail.com

Wojciech Wokurka: https://orcid.org/0000-0001-9936-5656 ; wojciechwokurka@gmail.com

Iga Dudek: https://orcid.org/0000-0002-8101-074X ; iga.dudek6@gmail.com

Piotr Piech:  https://orcid.org/0000-0001-8717-7957  ; ppiotr.md@gmail.com

Abstract

Idiopathic avascular necrosis of the femoral head, known as Legg-Calve-Perthes disease (LCPD), is one of the most common necrosis among paediatric patients. Although it was described over 110 years ago its aetiology is still not established. Neither have effective treatment methods, which main aim is to maintain the joint with a full range of motion and to reduce the risk of developing degenerative changes. According to the literature, the exact aetiology of LCPD has still not been established. Increasingly, immunological and genetic disorders are highlighted in the literature, which may be an important cause of disease development. However, the number of reliable studies on this subject is very limited. Once again, the influence of various risk factors present in fetal life has been analysed, but in a study with a significantly larger group of subjects. It has been repeatedly stressed that age, stage and radiological classification have a very important influence on the choice of treatment method and its effectiveness. Another important aspect is the need for reliable clinical trials to determine the effectiveness of bisphosphonate drugs and BMPs (bone morphogenetic proteins). In all studies, the need to perform more studies, on quantitatively larger groups of subjects, is significantly emphasized.

Key words: Legg-Calve-Perthes disease, Idiopathic avascular necrosis of the femoral head, etiology