Published August 6, 2021 | Version v1
Other Open

Data and Code from: Fasting Blood Glucose as a Predictor of Mortality: Lost in Translation

Creators

  • 1. Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA
  • 2. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD 21224, USA
  • 3. Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA, Vascular Biology and Therapeutics Program, Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.
  • 4. Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA
  • 5. The Jackson Laboratory, Bar Harbor, ME 04609, USA
  • 6. School of Public Health, Indiana University, Bloomington, IN 47405, USA
  • 7. Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USA
  • 8. Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA

Contributors

  • 1. School of Public Health, Indiana University, Bloomington, IN 47405, USA

Description

Aging leads to profound changes in glucose homeostasis, weight, and adiposity- which are considered good predictors of health and survival in humans. Direct evidence that these age-associated metabolic alterations are recapitulated in animal models is lacking, impeding progress to develop and test interventions that delay the onset of metabolic dysfunction and promote healthy aging and longevity. We compared longitudinal trajectories, rates of change and mortality risks of fasting blood glucose, body weight and fat mass in mice, nonhuman primates, and humans throughout their lifespans, and found similar trajectories of body weight and fat in the three species. In contrast, fasting blood glucose decreased late in life in mice but increased over the lifespan of nonhuman primates and humans. Higher glucose was associated with lower mortality in mice, but higher mortality in nonhuman primates and humans, providing a cautionary tale for translating age-associated metabolic changes from mice to humans. Aging leads to profound changes in glucose homeostasis, weight, and adiposity- which are considered good predictors of health and survival in humans. Direct evidence that these age-associated metabolic alterations are recapitulated in animal models is lacking, impeding progress to develop and test interventions that delay the onset of metabolic dysfunction and promote healthy aging and longevity. We compared longitudinal trajectories, rates of change and mortality risks of fasting blood glucose, body weight and fat mass in mice, nonhuman primates, and humans throughout their lifespans, and found similar trajectories of body weight and fat in the three species. In contrast, fasting blood glucose decreased late in life in mice but increased over the lifespan of nonhuman primates and humans. Higher glucose was associated with lower mortality in mice, but higher mortality in nonhuman primates and humans, providing a cautionary tale for translating age-associated metabolic changes from mice to humans.

Files

ISG Cell Metabolism archived data and code to share.zip

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