Relationships between geomagnetic Ар-indeх and parameters of the immunity in patients with multiple sclerosis and radiculopathies

Popovych Igor L., Gozhenko Anatoliy I., Badiuk Nataliya S., Napierała Marek, Muszkieta Radosław, Zukow Walery, Yanchij Roman I., Lapovets’ Natalia Ye., Lapovets’ Lyubov Ye., Tserkovnyuk Ruslan G., Akimova Viorica M., Nahurna Yaryna V., Martianova Olha I., Vivchar Roman Ya., Chendey Ivanna V., Ruzhylo Sofiya V. Relationships between geomagnetic Ар-indeх and parameters of the immunity in patients with multiple sclerosis and radiculopathies. Journal of Education, Health and Sport. 2021;11(3):77-90. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.03.009

https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.03.009

https://zenodo.org/record/4636917

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Received: 15.02.2021. Revised: 26.02.2021. Accepted: 25.03.2021.

Relationships between geomagnetic Ар-indeх and parameters of the immunity in patients with multiple sclerosis and radiculopathies

Igor L. Popovych¹, Anatoliy I. Gozhenko², Nataliya S. Badiuk³, Marek Napierała⁴, Radosław Muszkieta⁵, Walery Zukow⁶, Roman I. Yanchij⁷, Natalia Ye. Lapovets’⁸, Lyubov Ye. Lapovets’⁹, Ruslan G. Tserkovnyuk¹⁰, Viorica M. Akimova¹¹, Yaryna V. Nahurna¹², Olha I. Martianova¹³, Roman Ya. Vivchar¹⁴, Ivanna V. Chendey¹⁵, Sofiya V. Ruzhylo¹⁶

^1,2,3,10State Enterprise Ukrainian Research Institute for Medicine of Transport, Ministry of Health of Ukraine, Odesa, UKRAINE

⁴University of Economy, Bydgoszcz, POLAND

^5,6Nicolaus Copernicus University, Torun, POLAND

^1,7OO Bohomolets’ Institute of Physiology, Kyїv, UKRAINE

^{8,9,11,12,13,14,15}Danylo Halyts’kyǐ National Medical University, L’viv, UKRAINE

¹⁶Ivan Franko Pedagogical University, Drohobych, UKRAINE

Corresponding Author Walery Zukow E-mail: w.zukow@wp.pl

Abstract

Background. The effect of geomagnetism on human immunity has so far been studied through long-term observations. We set ourselves the goal of detecting the immediate immunotropic effects of the Earth's magnetic field by analyzing the relationships between immunity parameters and the geomagnetic Ap-index. Material and methods. The object of observation were 74 patients with multiple sclerosis and 14 patients with radiculopathies, who in the period from September 2014 to November 2018 conducted a one-time assessment of immune status by the relative content in the blood of lymphocytes of CD3⁺, CD4⁺, CD8⁺, CD25⁺, CD56⁺ and CD19⁺ phenotypes and serum level of Immunoglobulines M, G, A as well as CIC and IL-1β. On the day of blood capture and during the previous 7 days, retrospectively recorded the geomagnetic Ap-index, using a publicly available information resource http://wdc.kugi.kyoto-u.ac.jp/kp/index.html. Results. During the week, the average level of Ap-index ranged from 12÷20 nT. The correlation coefficients between the Ap-index on the day of blood collection and 1, 3 and 7 days before it and the level of CD3⁺CD4⁺ lymphocytes were -0,57; -0,48; -0,55 і -0,52 respectively, while on other days were in the range of -0,35÷0,05. In contrast, with the level of CD56⁺ lymphocytes Ap-index correlates positively and almost mirror (0,56; 0,43; 0,54 і 0,57 respectively and 0,34÷-0,08), due to the reciprocity of their levels (r=-0,80). Also positive, but much weaker, correlates the Ap-index with the level of CD25⁺ lymphocytes (0,35; 0,25; 0,45 і 0,31 respectively and 0,22÷-0,14). In contrast, with the level of IL-1β Ap-index correlates significantly only on the day of blood collection and 2 days before (r=0,21 and 0,31 respectively), and with other registered parameters of immunity the correlation is insignificant. The canonical correlation between Ap-indices for 7 days before and on the day of blood collection, on the one hand, and the levels of CD4⁺, CD56⁺, CD25⁺ and CD8⁺ lymphocytes and the concentration of IgM and IL-1β - on the other hand, was very strong: R=0,741; R²=0,549; χ²₍₄₂₎=130; p<10^-6. Conclusion. Disturbances of the geomagnetic field (Ap-index) has a significant immediate modulating effect on the level of immune parameters in the blood, mostly T-helpers (suppressor) and natural killers (enhancing).

Key words: geomagnetic Ap-index; immune status; multiple sclerosis; radiculopathy.