Journal article Open Access

FORMULATION AND EVALUATION OF ANTIBACTERIAL GEL USING LEAF EXTRACT OF ANDROGRAPHIS PANICULATA

Rashmi D. Zode*, C.M Chakole

Andrographis Paniculata is an annual herbaceous plant in the family of acanthaceae native to India and Shrilanka. Andrographis Paniculata has shown anti-bacterial property which makes it an essential herb in the treatment of various infections. This study was to check the effectiveness of Andrographis Paniculata against the microbial species Staphylococcus aurens, to observe the zone of inhibition and to develop a topical gel formulation of Andrographis Paniculata for the treatment of acne. The extraction was done by maceration method and continues with phytochemical screening and herbal gel formulation using hydroxypropyl methyl cellulose as a base with different concentration 2%v/v, 4%v/v, 6%v/v and 8%v/v. The gel was evaluated for the physical appearance, ph, homogenicity and antibacterial activity. Different concentration of Andrographis paniculata methanolic extract exhibited relatively good antibacterial activity. It was concluded that the gel formulation having higher concentration (8%) is found to be good consistency compared to 2%, 4%, and 6%v/v and can be used to treat the antibacterial activity.

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