Published April 1, 2019
| Version v1
Journal article
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A Critical Review on Adaptive Sample Size Re-estimation (SSR) Designs for Superiority Trials with Continuous Endpoints
Creators
- 1. Division of Biometrics VI, Office of Biostatistics, Center for Drug Evaluation and Research, FDA,USA
Description
Adaptive sample size re-estimation (SSR) methods have been widely used for designing clinical
trials, especially during the past two decades. We give a critical review for several commonly used
two-stage adaptive SSR designs for superiority trials with continuous endpoints. The objective,
design and some of our suggestions and concerns of each design will be discussed in this paper.
Keywords: Adaptive Design; Sample Size Re-estimation; Review
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