Deliverable 9.2: Specific recommendations regarding implementation of mechanism‐based test strategy for harmonised cumulative risk assessment according OECD, WHO, EFSA and EuroMix Guidance

The purpose of Task 9.2 was to summarise the key objectives and outcomes of the EuroMix WPs, to
highlight the findings of Deliverable 9.1 as summarised in the position paper (Rotter, Beronius et al.
2019) and to briefly present the outcome of the four international harmonisation workshops as well
as the WHO consultation in Geneva 2019. Building on those achievements, Task 9.2 aims to make
recommendations addressing risk managers in the EU, i.e. EU Commission, regarding implementation
of a harmonised assessment of combined exposure to multiple chemicals on the one hand and
regulatory needs such as improved harmonisation between EFSA, SCoPAFF, OECD and WHO on the
other.
The present report therefore aims to provide a very brief overview on the EuroMix project by
highlighting the most relevant findings and summarising its conclusions for improvement of new
guidance documents for risk assessment of combined exposure to multiple chemicals.
The report also considers the implementation of the recently published EFSA Guidance on
harmonized methodologies for human health, animal health and ecological risk assessment of
combined exposure to multiple chemicals (EFSA 2019), EFSA Statement – Genotoxicity assessment of
chemical mixtures (EFSA 2019) as well as the OECD Considerations for Assessing the Risks of
Combined Exposure to Multiple Chemicals with regard to future research and development needs
(OECD 2018).
Further recommendations regarding the EuroMix toolbox are summarised in Deliverable 8.4 “Report
with recommendation for OECD and other international organisations”.