Preparation and in-vitro Evaluation of Modified Release Tablets based on Cefuroxime Axetil and Comparison with Conventional tablets

Modified-Release oral dosage forms including Extended-Release have many advantages over traditional oral dosage forms, especially in improving bioavailability, improving patient compliance, and reducing relating adverse effects. In this research extended-release tablets of Cefuroxime Axetil (CA) were prepared using proper concentrations of hydrophilic polymers, these tablets were designed to be gastro-retentive too by Floating and Bioadhesion mechanisms. A gas-generation material was included to make the tablets float over gastric content, bioadhesive polymers were also included to make the tablets adhere to gastric mucosa when stomach is empty. Carbopol 934p, high molecular weight Chitosan, HPMC K4Mm and HPMC K15M were worked on in different ratios, and the best polymer was blended with Carbopol 934p. The behavior of in-vitro CA releases in a medium that simulates the acidity of the stomach were studied, Physical interactions between active material and excipients were studied FTIR spectroscopy and Differential Scanning Calorimetry DSC. The results show that the formula containing a combination of HPMC K4M 15% and Carbopol 934p 5% complies with USP 38 criteria for Extended release within 12 hours.