Published July 14, 2025 | Version v1
Dataset Open

Age-Dependent Effect of Environmental Enrichment on the Neural 3D Chromatin Interactome (datasets and additional files)

Creators

  • 1. Cancer Epigenetics and Nanomedicine Laboratory, Nanomaterials and Nanotechnology Research Center (CINN), Spanish National Research Council (CSIC), El Entrego, Asturias, 33940, Spain.
  • 2. Health Research Institute of the Principality of Asturias (ISPA), Oviedo, Asturias, 33011, Spain.
  • 3. Department of Translational Neuroscience, Cajal Institute (IC), Spanish National Research Council (CSIC), Madrid, Comunidad de Madrid, 28002, Spain
  • 4. Josep Carreras Leukaemia Research Institute (IJC), Badalona, Cataluña, 08916, Spain.

Description

Aging is a multifactorial biological process resulting in physiological and cellular decline. However, our understanding of age-related changes in 3D genome organization and the effect of external interventions on this process, remains limited. Here we performed low input Promoter Capture Hi-C (liCHi-C) and RNA-seq in hippocampal neurons of young and old mice which were also exposed to environmental enrichment (EE). In this study, we characterized the impact of age and cognitive and physical stimulation on chromatin interactome organization and gene expression.

This dataset contains processed data and additional files related to the manuscript.

Files

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