Biological processes operate through molecular networks at the cellular level and cell–cell communication networks at the tissue/organ level. Deciphering the wiring and rewiring of these networks under normal and pathologic conditions is a fundamental goal of biomedical research. Our lab is focused on developing data-driven systems biology algorithms to integrate bulk, single-cell, and spatial omics data to decipher these (re)wiring events and hidden drivers underpinning biological processes in health and disease. Ultimately, we aim to translate the hidden driver discoveries into therapeutic targets, biomarkers, and combination therapies for cancer and other disorders.