At its best, science communication can empower research and innovation systems to address global challenges, by improving the relationships with stakeholders in policy, industry, and civil society. Science communication can put public interests at the heart of how knowledge is produced, shared, and applied today, thereby enhancing the benefits of science and technology and mitigating their limitations or risks. Moreover, effective science communication can facilitate the role of research and innovation in developing a more sustainable world. Therefore, it is imperative that science communication plays its mediating role effectively.