Recent studies highlight the potential impact of climate change and geo-hazards (such as landslides and earthquakes) on historic areas, hosting cultural heritage sites and monuments, which in turn yield significant adverse impacts on economies, politics, and societies. The deterioration of cultural heritage sites is one of the biggest challenges in conservation; Currently, there is no specific process towards understanding and quantifying climate change effects on historic areas; combined with the limited strategies on climate change-related issues, it becomes difficult to assess quantitatively and qualitatively the impact of various climatic and other parameters on the cultural heritage sites. These issues form an integral part of the necessary support that should be provided to governmental bodies and cultural authorities to properly adapt their policies, in the short and long term, towards deploying sustainable mitigation plans and providing efficient reconstruction of the cultural heritage parts that have been damaged. Finally, the absence of social and humanities and communities’ participatory aspects to the overall resilience and reconstruction planning of the historic areas is the main challenge to tackle. HYPERION takes into account the local eco-systems in the cultural heritage areas, mapping out their interactions and following a truly integrated/sustainable reconstruction approach (technical, social, institutional, environmental, and economic level), by incorporating active communities participation and by supporting new business models based on the concept of a “load-balancing” economy, and offering financial risk-transfer tools that can ensure the immediate funds' availability to fuel timely build-back-better efforts. HYPERION aims to use existing tools and innovative technologies and create an integrated resilience assessment platform, in which end users will be able to have a better understanding of the dangers and threats of tangible cultural heritage, make decisions for a swifter and more effective response, and contribute to the sustainable reorganization of the historical regions under threat.