The DISTENDER project develops a methodological framework to bring together adaptation and mitigation strategies against the risks of climate change and to enable their creation through participatory processes of those involved in decision-making. Based on localized information from six main case studies at national, regional, and local levels, as well as various mathematical models, quantitative and qualitative analyses are conducted. Taking into account cross-sectoral impacts at different levels, these analyses facilitate the understanding of interactions, synergies and trade-offs between different possible strategies. Accompanied by five follower case studies, the knowledge generated will be made available through a digital decision support system, thus enabling further cities and regions to plan their climate change strategies in a transversal and interdisciplinary way.