The Royal College of Surgeons in Ireland (RCSI) is leading an international team of scientists on a major research study “COLOSSUS” which aims to provide new and more effective ways to classify and treat patients with metastatic colorectal cancer (mCRC). The project specifically focuses on microsatellite stable RAS mutant (MSS RAS mt) disease; a genetically defined form of mCRC which is incurable once patients develop resistance to existing therapies. The ultimate aim is to better classify subtypes of this condition and deliver new personalised treatments and improved patient outcomes specifically for this patient sub-group. For more information visit https://www.colossusproject.eu/. COLOSSUS has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 754923.