The BIOCTANE project aims to develop and optimize an innovative process for the conversion of organic waste materials naturally characterized by a high-water content (e.g. food-waste, organic material from the food processing industry) into carbon-neutral market-ready drop-in jet-fuels. In particular, BIOCTANE project will develop a proof of concept on the synergetic coupling of biotechnological and thermocatalytic processing routes by a disruptive and interdisciplinary strategy that will result in an efficient valorisation of the organic wastes into renewable jet-fuel, maximizing the recovery of chemical energy, nutrients and carbon use. First, the complex organic waste will be converted into platform molecules (acetoin and 2,3-butanediol) by creating a breakthrough link between biotechnological processing of biowaste and hydrothermal gasification technology. Subsequently, a novel one-pot chemical process will be developed by the combination of different catalytic steps through which the platform molecules are converted to jet-fuel range hydrocarbons. Based on an extensive process flow modelling, the process efficiency and the techno-economic requirements for full market integration as well as the environmental impact will be assessed. Therefore, BIOCTANE will establish a novel pathway involving hybrid processes and multifunctional catalysts, contributing to implement sustainable, secure and competitive renewable energy technologies in Europe, boosting the use of advanced biofuels and with a direct impact on strategic areas like aviation transport.