The Texas A&M Drug Discovery and Development Resource Center (3DRC) and the Gulf Coast Consortia Drug Discovery Resource Center (DDRC) operate as translational research engines embedded within the TMC3 Helix Park Collaborative Building in Houston, TX. Our mission is to advance early-stage therapeutic discovery through high-throughput screening (HTS), computational design, chemical synthesis, and physiologically relevant model systems.

This Zenodo community serves as a public-facing data companion to our main portal at https://tamu-3drc.github.io. It provides centralized access to curated datasets, analysis outputs, assay protocols, and related metadata generated through our NIH- and CPRIT-funded programs, including:

• Single-Agent Drug Screens (HTS, dose–response, organoid viability)

• Combinatorial Drug Screens (SynergyFinder, ZIP/Bliss/HSA models)

• Flow Cytometry Campaigns (spectral, high-parameter)

• Image-Based Phenotypic Screens (2D/3D morphology, deepOrganoid analysis)

• Optical Metabolic Imaging & Electrophysiology

We host data aligned with rigorous quality control metrics, including Z′-factor, Minimum Significant Ratio (MSR), and dose–response reproducibility scores.

This site supports:

• Academic transparency and FAIR data principles

• Reproducibility of drug discovery studies

• Open access to curated results from public and collaborative research

• Extensibility for downstream AI, pharmacogenomics, and mechanism-of-action studies

Citation guidance and CPRIT grant acknowledgement language are included with each dataset release.