An Overall Review on Colon Specific Drug Delivery System

 Numerous drug entities based on oral delivery have been successfully commercialized, but many others are not readily available by oral administration, because they are incompatible with the physical and chemical environments of the upper gastrointestinal tract (GIT) and demonstrate poor uptake in the upper GI tract. Due to the lack of digestive enzymes, colon is considered as suitable site for the absorption of various drugs. Over the past two decades the major challenge for scientist is to target the drugs specifically to the colonic region of GIT. Previously colon was considered as an innocuous organ solely responsible for absorption of water, electrolytes & temporary storage of stools. But now it is accepted as important site for drug delivery. In this review we focused on different approaches for colonic delivery and major applications of colonic drug delivery system.