Development And Evaluation Of Pressed Coated Floting Pulsatile Tablet Of Atenolol

Atenolol is an Synthetic Beta-1 selective blocker, primarily used in management of hypertension and Chronic angina and to reduce mortality in known or suspected myocardial infarction. It belongs to BCS class III having a half-life of 7hrs and 50% bioavailability.  The purpose of the present work was to design and optimize compression coated floating pulsatile drug delivery systems of Atenolol as an antihypertensive agent. The prepared system was composed of two components: an active ingredient-containing core tablet and an erodible outer shell with a gas-producing agent. The active component was combined with super disintegrates to create the rapid release core tablet (RRCT). By using polymer, the optimized RRCT was press coated. The optimization procedure made use of a 32 complete factorial design. As independent variables, Avicel pH 102 and the quantity of HPMC K200M were used. Lag time and hardness were selected as dependent variables. Floating pulsatile release formulation (FPRT) F8 at level +1 (100mg) for HPMC K200M and level -1 (20mg) for Avicel pH 102 showed lag time of 6 h with >90% drug release. The values of n were more than 1.