Published March 22, 2023 | Version 1
Journal article Open

4-year survival and biomarkers evaluation from a phase II study of sequential immunotherapy and targeted therapy for metastatic BRAF V600-mutated melanoma (SECOMBIT)

  • 1. Department of Melanoma, Cancer Immunotherapy and Development Therapeutics. I.N.T. IRCCS Fondazione "G. Pascale" Napoli
  • 2. Immuno-Oncology & Targeted Cancer Biotherapies, University of Sassari - Unit of Cancer Genetics, IRGB-CNR, 07100 Sassari, Italy
  • 3. Immunotherapy, Cell Therapy Unit and Biobank Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy
  • 4. Melanoma Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy
  • 5. Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy
  • 6. 6 University of Perugia, Perugia, Italy
  • 7. Biotherapy of Tumors Unit, Department of Experimental Oncology, European Institute of Oncology, IRCCS, Milan, Italy
  • 8. Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska Curie National Research Institute of Oncology, 02-781 - Warsaw/PL
  • 9. Department of Medical Oncology 1, IRCCS Regina Elena National Cancer Institute, Rome, Italy
  • 10. Department of Medical Oncology, Hospital Clínic Barcelona, 08036 - Barcelona/ES
  • 11. Rare tumors and Melanoma Unit, IRCCS Istituto dei Tumori "Giovanni Paolo II", Bari, Italy
  • 12. Oncology Unit, Foundation IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
  • 13. First Department of Medicine, National and Kapodistrian University of Athens, Greece
  • 14. Department of Dermatology, Medical University of Graz, Graz, Austria
  • 15. Department of Medical Sciences, Dermatologic Clinic, University of Turin, Turin, Italy
  • 16. Université Paris Cite, Dermato-Oncology and CIC AP-HP Hôpital Saint Louis,Cancer Institute APHP.Nord-Université Paris Cite F-75010 Paris, France; INSERM U976
  • 17. Department of Oncology-Pathology, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden
  • 18. IRCCS Ospedale Policlinico San Martino, Skin Cancer Unit, Genova, Italy
  • 19. Department of Interdisciplinary Medicine, Oncology Unit, University of Bari "Aldo Moro", Bari, Italy
  • 20. Unit of Melanoma Medical Oncology, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
  • 21. Department of Medical Oncology, University Hospital Dexeus, Barcelona, Spain
  • 22. Academic Hospital "Santa Maria della Misericordia", Udine, Italy
  • 23. Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy
  • 24. Department of Immunology and Oncology, Clínica Universidad de Navarra, Pamplona, Spain
  • 25. Medical Oncology Unit, AORN San Pio Benevento
  • 26. Fondazione Policlinico Universitario A. Gemelli, IRCCS – Facility of Epidemiology and Biostatistics, Rome
  • 27. Department of Dermatology, University and University Hospital Zurich, Zurich, Switzerland

Description

4-year survival data of clinical trial SECOMBIT

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