Dryad
Published September 18, 2023 | Version v1
Dataset Open

Myomatrix arrays for high-definition muscle recording

Authors/Creators

  • 1. Emory University
  • 2. Georgia Institute of Technology
  • 3. Western University
  • 4. Columbia University
  • 5. Champalimaud Foundation
  • 6. Tufts University
  • 7. Johns Hopkins Medicine
  • 8. Salk Institute for Biological Studies
  • 9. University of Colorado Anschutz Medical Campus
  • 10. Drexel University
  • 11. Temple University

Description

Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nervous system's actual motor output – the activation of muscle fibers by motor neurons – typically cannot detect the individual electrical events produced by muscle fibers during natural behaviors and scale poorly across species and muscle groups. Here we present a novel class of electrode devices ("Myomatrix arrays") that record muscle activity at cellular resolution across muscles and behaviors. High-density, flexible electrode arrays allow for stable recordings from the muscle fibers activated by a single motor neuron, called a "motor unit", during natural behaviors in many species, including mice, rats, primates, songbirds, frogs, and insects. This technology therefore allows the nervous system's motor output to be monitored in unprecedented detail during complex behaviors across species and muscle morphologies. We anticipate that this technology will allow rapid advances in understanding the neural control of behavior and in identifying pathologies of the motor system.

Notes

Funding provided by: National Institute of Neurological Disorders and Stroke
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000065
Award Number: R01NS084844

Funding provided by: National Institute of Neurological Disorders and Stroke
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000065
Award Number: R01NS109237

Funding provided by: National Institute of Neurological Disorders and Stroke
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000065
Award Number: R01NS099375

Funding provided by: National Institute of Neurological Disorders and Stroke
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000065
Award Number: R01EB022872

Funding provided by: National Institute of Neurological Disorders and Stroke
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000065
Award Number: U24NS126936

Funding provided by: National Science Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000001
Award Number: 1822677

Funding provided by: National Science Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000001
Award Number: DGE-1937971

Funding provided by: National Science Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000001
Award Number: DGE-1444932

Funding provided by: McKnight Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100005270
Award Number:

Funding provided by: Azrieli Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100005155
Award Number:

Funding provided by: Novo Nordisk Fonden
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100009708
Award Number:

Funding provided by: Kavli Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100001201
Award Number:

Funding provided by: Simons Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000893
Award Number:

Funding provided by: Halle Institute for Global Research, Emory University
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100019070
Award Number:

Files

README.md

Files (16.0 GB)

Name Size Download all
md5:d276931bf35a1cfc1b9ce9d8fadb198f
4.0 kB Download
md5:b6aafb63e1f836358e226b84d20a7a01
4.4 kB Download
md5:70cfe518ae6a8df643bf81720474debb
719 Bytes Download
md5:34dd2dd24480efac7061a99c2481c460
3.6 kB Download
md5:31924cda9e8c6dca127a4002803e1832
558 Bytes Download
md5:b802b80c9a450726fbad2986d6f82b5f
11.2 GB Download
md5:ec8aeff4dd7a5818ea967c2c925767cc
3.8 GB Download
md5:e3cf7d0b47f49e285f52e62f543df43e
461.0 MB Download
md5:a23b596227119d697683cd61ce7e9c95
447.5 MB Download
md5:ddc2298858071a25b5c7b530b51d7b59
6.2 kB Preview Download

Additional details

Related works

Is cited by
10.7554/elife.88551.1 (DOI)