EVALUATION OF THE RESULTS OF THE TREATMENT OF NON-SPECIFIC ULCERATIVE COLITIS WITH THE APPLICATION OF PLASMAPHERESIS

Objective: Improving the results of treatment of steroid-dependent and steroid-resistant forms of ulcerative colitis.

Methods: The study is based on the results of treatment of 105 patients with nonspecific ulcerative colitis with hormone-resistant and hormone-dependent forms, admitted to the surgical departments of the multidisciplinary clinic of Samarkand State Medical University in the period from 2012 to 2021.

Results: In patients of the main group on the background of plasmapheresis, we received a complete response in 30 (64%) of 47 patients, an incomplete response in 15 (32%) patients, a partial response in 2 (4%) patients. In patients of the control group, the results of treatment during these periods were significantly worse than in patients of the main group.

Conclusions: The positive dynamics of general clinical, laboratory parameters and endoscopic picture in patients with steroid - dependent and steroid - resistant forms of ulcerative colitis when using for their treatment a course of plasmapheresis with indirect electrochemical detoxification of blood plasma with additional ozonation indicates its effectiveness in stopping the exacerbation of the disease.