Wild pedigrees inform mutation rates and historic abundance in baleen whales
Creators
- 1. University of Groningen
- 2. Grønlands Naturinstitut
- 3. National Institute of Aquatic Resources*
- 4. Mingan Island Cetacean Study Inc*
- 5. Center for Coastal Studies
Description
Phylogeny-based estimates suggesting a low germline mutation rate (μ) in baleen whales have influenced research ranging from assessments of whaling impacts to evolutionary cancer biology. We estimated μ directly from pedigrees in four baleen whale species for both the mitochondrial control region and nuclear genome. The results suggest values higher than those obtained through phylogeny-based estimates and similar to pedigree-based values for primates and toothed whales. Applying our estimate of μ reduces previous genetic–based estimates of pre-exploitation whale abundance by 86% and suggests that μ cannot explain low cancer rates in gigantic mammals. Our study shows that it is feasible to estimate μ directly from pedigrees in natural populations, with wide-ranging implications for ecological and evolutionary research.
Notes
Funding provided by: H2020 Marie Skłodowska-Curie Actions
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100010665
Award Number: 813383
Funding provided by: National Marine Fisheries Service
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100013408
Award Number:
Funding provided by: Rijksuniversiteit Groningen
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001721
Award Number:
Funding provided by: Aage V. Jensens Fonde
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100002721
Award Number:
Funding provided by: Consejo Nacional de Ciencia y Tecnología
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100003141
Award Number:
Funding provided by: WWF Verdensnaturfonden
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100013939
Award Number:
Funding provided by: International Whaling Comission Scientific Committee
Award Number:
Funding provided by: Kommissionen for Videnskabelige Undersøgelser i Grønland
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100004797
Award Number:
Funding provided by: Greenland Home Rule
Award Number:
Files
README.md
Files
(171.6 MB)
| Name | Size | Download all |
|---|---|---|
|
md5:e00953d93eb7d10ab91da76c002a2acb
|
8.1 kB | Preview Download |
|
md5:89808c5160b1286518822f81f67d1702
|
171.6 MB | Preview Download |
Additional details
Related works
- Is cited by
- 10.1101/2022.10.06.510775 (DOI)