Published April 30, 2021
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Fig. 12 in Toonaones A I, limonoids with NLRP3 inflammasome inhibitory activity from Toona ciliata M. Roem
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Fig. 12. In vitro bioactivity of compounds 3–14. (A) Primary screening of compounds from Toona ciliata against LDH release (n = 2). MCC950 (1 μM) was used as a positive control. Compounds with LDH release level lower than 50% were marked by arrows. (B) IC50 values of potent compounds in an LDH release assay (n = 2). These compounds were low cytotoxic with CC50 values above 20 μM. (C) Inhibition of LDH and IL-1β release (n = 2). (D) PI (propidium iodide) uptake by fluorescent microscopy (n = 1). (E–G) Western blot assays of GSDMD, Casp- 1, and IL-1β (n = 1). Compared to LPS + Nig group, *P <0.05, **P <0.01. LPS, lipopolysaccharide. Nig, Nigericin. FL, full length. NT, N-terminal.
Notes
Published as part of Shi, Qiang-Qiang, Zhang, Xing-Jie, Wang, Ting-Ting, Zhang, Yu, Zeb, Muhammad Aurang, Zhang, Rui-Han, Li, Xiao-Li & Xiao, Wei-Lie, 2021, Toonaones A I, limonoids with NLRP3 inflammasome inhibitory activity from Toona ciliata M. Roem, pp. 1-11 in Phytochemistry (112661) 184 on page 9, DOI: 10.1016/j.phytochem.2021.112661, http://zenodo.org/record/8292111
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- Journal article: 10.1016/j.phytochem.2021.112661 (DOI)
- Journal article: urn:lsid:plazi.org:pub:FFB7FF8C2445694CFFB0301BA710BB0E (LSID)
- Journal article: https://zenodo.org/record/8292111 (URL)