Published August 25, 2023
| Version v1
Journal article
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Effect of Carvedilol in Portal Hypertensive Gastropathy (PHG)
- 1. 1Ph.D Scholar, Division of Surgery, ICAR-Indian Veterinary Research Institute, Izzatnagar, U P 2Assistant Professor, Department of Veterinary Medicine, CVSc & AH Selesih, Mizoram 3Assistant Professor, Department of Veterinary Clinical Complex, Faculty of Veterinary and Animal Sciences, RGSC-Banaras Hindu University, Barkachha, Mirzapur, U P 4Assistant Professor, Department of Surgery and Radiology, Bihar Veterinary College, BASU Patna, Bihar 5BVSc & AH, Veterinary College Shivamogga, KVAFSU Bidar, Karnataka
Description
Carvedilol is a potent beta-blocker with mild anti-alpha 1 adrenergic activity, offering therapeutic potential in various medical contexts. Its nonselective beta-blocking action results in decreased heart rate and cardiac output and induces splanchnic vasoconstriction, thereby reducing portal blood inflow and lowering portal pressure. This holds particular significance in addressing conditions like Portal Hypertensive Gastropathy (PHG), which is associated with chronic anaemia in cirrhosis patients. A key therapeutic aim in managing PHG is the reduction of portal pressure.
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