Glyphosate and Oxidative Stress: ECHA's superficial approach neglects existing hazards

Oxidative stress does not need to be generated from chemicals directly but can result from the interference of the compound with the endogenous ROS cycle. While guideline studies do not contain endpoints covering this aspect, oxidative stress has been demonstrated extensively for glyphosate in academic studies. ECHA’s risk assessment committee failed to use an appropriate weight of evidence approach by matching the existing mechanistic evidence with the statistically significant increases in tumour incidences seen in the carcinogenicity studies. Instead of performing a comprehensive integrated review of existing evidence, ECHA overlooked a large number of studies and dismissed others based on their isolated consideration using oversimplified arguments.