Mapping Immunogenic Regions In SARS-CoV-2 to Understand Vaccine Design Using Bioinformatics
- 1. Department of Liberal Arts & Sciences, Waubonsee Community College, Sugar Grove, Illinois
- 2. Cleveland Clinic; Cleveland, OH
- 3. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California
Disparities in undergraduate STEM degree completions across the United States are a national concern. Undergraduate-level research opportunities are vital for developing future researchers and building their scientific identity. These experiences can help students in community colleges acquire 21st-century skills and build confidence in their ability to do science [1-3]. The development and implementation of guided research experiences provide users with a topic they are familiar with but not necessarily experts in, like SARS-CoV2 infections. In this particular study, the Immune Epitope Database (IEDB) was used to identify amino acid residues located on the immunogenic regions of the spike glycoprotein of SARS-CoV-2 variants: Alpha, Beta, Gamma, Delta, and Omicron. IEDB is a web-based bioinformatics tool that contains published epitope information and prediction aids that can be used as a research platform for studying infectious diseases. The objective of this study aimed to map the immunogenic regions on the spike glycoproteins of the SARS-CoV-2 variants and predict the immune evasion of these variants [4-6]. Identifying the antigenic determinations that bind to the antibodies is essential for designing future candidates for peptide-based vaccines.
This study aims to map the immunogenic regions on the spike glycoproteins of the SARS-CoV-2 variants and predict the immune evasion of these variants [4-6]. Identifying the antigenic determinations that bind to the antibodies is essential for designing future candidates for peptide-based vaccines. This research identifies regions where mutations have occurred in the virus, which are important to study as they can affect the virus's immune evasion and impact available vaccines. Targeting multiple immunogenic regions unaffected by mutations can serve as potential targets for new vaccines, providing better protection against different variants.
JATE_S. Vemu_ Mapping Immunogenic Regions_Final_DOI.pdf
- Developing Classroom-based Undergraduate Research Experiences in Antibody Bioengineering 2055036
- National Science Foundation