The Effects of Passive Smoking on the Placental Barrier: A Light Microscopic Study
- 1. Department of Anatomy, Subharti Medical College, Delhi-Haridwar Bypass Road, Meerut -250002 (U.P.)
- 2. Pathology, Subharti Medical College, Delhi-Haridwar Bypass Road, Meerut -250002 (U.P.)
Description
Passive exposure to tobacco smoke causes ultrastructural changes in placental vasculature. It was endeavoured
to observe under the light microscope, the endothelial cells of the capillaries and to look for microscopic changes in the
vasculosyncytial membranes in the terminal villi of placentae of passive smokers exposed largely to bidi smoke. To study
effect of passive smoking on placental vasculature a total of 150 placentae were selected from healthy full term gravidas
with no history of tobacco use. They were divided into two group viz; passive smokers (n=87) and non passive smokers-
control (n=63). Three micron thick sections were cut, stained and examined under light microscope. The study revealed
that endothelial cells of stromal capillaries of the placental villi were oedematous resulting in irregular capillary lumina
(p=0.0007) and vasculosyncytial membrane was significantly absent in terminal villi of passive smokers in comparison to
control (p=0.0000).
Files
1 Dr.Srividya Sreenivasan.pdf
Files
(342.4 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:459bf14833af8395b9663a210d1958f8
|
342.4 kB | Preview Download |
Additional details
References
- 1. Asmussen I: Fetal cardiovascular system as influenced by maternal smoking. Clinical Cardiology, 1979;2(4): 246-256.
- 2. Asmussen I: Ultrastructure of human umbilical veins: observations on veins from newborn children of smoking and non-smoking mothers. Acta Obstetricia et Gynecologica Scandinavica, 1978; 57(3):253-255.
- 3. Asmussen I: Ultrastructure of the human placenta at term: Observations on placentae from newborn children of smoking and non-smoking mothers. Acta Obstetricia et Gynecologica Scandinavica, 1977;56(2):119-126.
- 4. Burton GJ, Palmer ME, Dalton KJ: Morphometric differences between the placental vasculature of non- smokers, smokers and ex-smokers. The British Journal of Obstetrics & Gynaecology, 1989;96(8):907-915
- 5. Gupta PC, Asma S. (Eds) Bidi smoking and public health. Ministry of Health and Family Welfare, Govt of India. Nirman Bhawan, New Delhi, 2008.
- 6. Lieberman E, Gremy I, Lang JM, Cohen AP: Low birth weight at term and the timing of fetal exposure to maternal smoking. American Journal of Public Health, 1994; 84(7):1127-1131.
- 7. Liebhart M: Polysaccharide surface coat (glycocalix) of human placental villi. Pathologia Europaea, 1974;9:3- 10
- 8. Luciano A, Bolognani M, Biondani P, Ghizzi C, Zoppi G, Signori E: The influence of maternal passive and light active smoking on intrauterine growth and body composition of the newborn. European Journal of Clinical Nutrition, 1998;52(10):760-763.
- 9. Palmieri D, Aliakbarian B, Casazza AA, Ferrari N, Spinella G, Pane B, Cafueri G , Perego P, Palombo D: Effects of polyphenol extract from olive pomace on anoxia- induced endothelial dysfunction. Microvascular Research, 2012;83(3):281-289.
- 10. Rath G, Dhuria R, Salhan S, Jain AK: Morphology and morphometric analysis of stromal capillaries in full term human placental villi of smoking mothers: an electron microscopic study. La Clinica Terapeutica, 2011;162(4): 301-305.
- 11. Tobacco smoking-Wikipedia, the free encyclopedia. URL:htpp://en.wikipedia.org/wiki/Tobacco_smoking. 2010.
- 12. Van der Veen F, Fox H: The effects of cigarette smoking on the human placenta: a light and electron microscopic study. Placenta, 1982;3(3):243-256.
- 13. WHO Report on the Global Tobacco Epidemic, MPOWER package 2008