People's Journal of Scientific Research
Published June 1, 2016 | Version v1
Journal article Open

Incidence of Reactive Thrombocytosis in Febrile Young Infants with Serious Bacterial Infections

Creators

  • 1. Department of Paediatrics, Maharani Laxmibai Medical College, Jhansi, Uttar Pradesh (India)

Description

The purpose of the present prospective study, conducted in a tertiary care paediatric unit during June 2013 to October 2014, was to estimate the incidence of reactive thrombocytosis among febrile young infants and assess the utility of platelet count as a potential predictor of serious bacterial infection (SBI). All infants 29 days to 1 year of age, admitted with 0 rectal temperature >38 C were included in the study. Out of the 100 infants studied, 46 had serious bacterial infection. Platelet counts were significantly higher in infants with SBI (60.87%) compared to those without (non SBI), (14%). Majority of infants in SBI group with thrombocytosis had respiratory tract infections (69.57 %, 16/23). Reactive 3 thrombocytosis was a frequent finding in young infants with SBI. Thrombocytosis ≥450,000 cells/mm , in combination with leucocytosis and elevated CRPmay help in early recognition of febrile young infants at risk for SBI

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References

  • 1. Baker MD, Avner JR, Bell LM. Failure of infant observation scales in detecting serious illness in febrile, 4- to 8-week-old infants. Pediatr1990;85(6):1040- 1043
  • 2. Hsiao AL, Baker MD. Fever in the new millennium: a review of recent studies of markers of serious bacterial infection in febrile children. Current Opinion Pediatrics 2005;17:56-61
  • 3. Mantadakis E, Tsalkidis A, Chatzimichael A. Thrombocytosis in childhood. Indian Pediatr 2008;45: 669-677
  • 4. Dame C, Sutor AH. Primary and secondary thrombocytosis in childhood. Br J Haematol 2005;129(2):165-77
  • 5. Larry J. Baraff, David L. Schriger, James W. Bass, Gary R. Fleisher, Jerome O. Klein, George H. McCracken et al. Practice guideline for the management of infants and children 0 to 36 months of age with fever without source. Pediatr 1993;92:1-12
  • 6. Yadav D, Chandra J, Sharma S, Singh V. Clinicohematological study of thrombocytosis. Indian J Pediatr,. 2010;77:643–647
  • 7. Matsubara K, Fukaya T, Nigami H, Harigaya H, Hirata T, Nozaki H, Baba K. Age-dependent changes in the incidence and etiology of childhood thrombocytosis. Acta Haematol 2004; 111: 132-137.
  • 8. O'Shea J, Sherlock M, Philip R. Thrombocytosis in childhood. Acta Haematol 2005; 113: 212
  • 9. Chan KW, Kaikov Y, Wadsworth LD. Thrombocytosis in childhood: a survey of 94 patients. Pediatr 1989; 84: 1064-1067.