Published April 30, 2022
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Carvone and its pharmacological activities: A systematic review
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- 1. Graduate Program in Health Sciences, Federal University of Sergipe, S˜ao Crist´ov˜ao, Sergipe, Brazil
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Pina, Lícia T.S., Serafini, Mairim R., Oliveira, Marlange A., Sampaio, Laeza A., Guimar˜aes, Juliana O., Guimar˜aes, Adriana G. (2022): Carvone and its pharmacological activities: A systematic review. Phytochemistry (113080) 196: 1-26, DOI: 10.1016/j.phytochem.2021.113080, URL: http://dx.doi.org/10.1016/j.phytochem.2021.113080
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- urn:lsid:plazi.org:pub:2C70FFCBA872FF91136107123402520F
References
- In 2008, Sousa et al. demonstrated for the first time that the (R)-( ) isomer produces a relaxing effect on isolated guinea pig ileum, suggesting an antispasmodic effect for carvone (Sousa et al., 2008). Subsequently, Consolini et al. (2011) reported that the effect of (R)-( )-carvone is related to the non-competitive inhibition of acetylcholine or calcium (Consolini et al., 2011). After that, in 2013, Souza et al. demonstrated that (R)-( )-carvone acts as a potent calcium channel blocker, presenting effects similar to an antagonist of these channels, verapamil (Souza et al., 2013). In addition, this isomer promotes relaxation of the intestinal smooth muscle and aortic rings, with significant effects on gastrointestinal motility (Silva et al., 2015; Sousa et al., 2015).
- The (S)-(+)-carvone also has a relaxing effect. However, less potent than (R)-( )-carvona (Sousa et al., 2008). In addition, (S)-(+)-carvone promotes muscle relaxant effects that help in inhibiting gastrointestinal motility (Silva et al., 2015). Similarly, the administration of (S)-(+ )-carvone promotes relaxing effects on aortic rings (Sousa et al., 2015).
- These results corroborate those obtained by Kundu et al. (2015) in which CARV inhibits the influx of calcium into the cell and reduces reactive oxygen species, reducing the contraction caused by Arsenic (III) and Mercury (II) in the rat trachea (Kundu et al., 2016). In this sense, this monoterpene also seems to be a molecule of interest for the control of muscle activity via the modification of calcium channels, with possible applicability in gastrointestinal, cardiovascular and respiratory disorders (Fig. 5).