Published February 29, 2020
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Fig. 2 in An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors
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- 1. , Damian McHugh & ∗ , Lucien Rufener & , Julia Hoeng & , & PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland
Description
Fig. 2. Representative traces of currents elicited by using the agonist mode (a and c) and PAM mode (b and d) in the whole-cell mode of the patch-clamp technique at a holding potential of −70 mV in CHO cells stably expressing human α4β2 (a and b) and human α7 (c and d) nAChRs. Agonist mode (a, c): 0.3% DMSO (left); 33.3 μM of the tobacco alkaloid anabasine (middle); 33.3 and 900 μM ACh for α4β2 and α7, respectively (right). PAM mode (b, d): 0.4 and 100 μM ACh for α4β2 and α7, respectively (left); co-application of 33.3 μM of the tobacco alkaloid trans-anatalline (middle); 0.4 or 100 μM ACh for α4β2 and α7, respectively (right). Thick dotted lines represent the pre-application period of the alkaloid (≥2 min). Thin dotted lines represent zero current.; PAM, positive allosteric modulator.
Notes
Published as part of Alijevic, Omar, McHugh, Damian, Rufener, Lucien, Mazurov, Anatoly, Hoeng, Julia & Peitsch, Manuel, 2020, An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors, pp. 1-20 in Phytochemistry (112187) 170 on page 9, DOI: 10.1016/j.phytochem.2019.112187, http://zenodo.org/record/8194187
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- Journal article: 10.1016/j.phytochem.2019.112187 (DOI)
- Journal article: urn:lsid:plazi.org:pub:FF8B0076FFF1FFC6C353A15AFFF83131 (LSID)
- Journal article: https://zenodo.org/record/8194187 (URL)