The current state of the problem of drug hepatotoxicity and measures of its prevention and treatment

SHMANKO, Volodymyr, SHMANKO, Oleh and LAZARCHUK, Tetyana. The current state of the problem of drug hepatotoxicity and measures of its prevention and treatment. Journal of Education, Health and Sport. 2023;30(1):106-115. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.30.01.010

https://apcz.umk.pl/JEHS/article/view/42110

https://zenodo.org/record/8192214

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of 17.07.2023 No. 32318. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 17.07.2023 Lp. 32318. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2023;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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Received: 27.06.2023. Revised: 26.07.2023. Accepted: 26.07.2023. Published: 28.07.2023.

The current state of the problem of drug hepatotoxicity and measures of its prevention and treatment

Volodymyr SHMANKO, Oleh SHMANKO, Tetyana LAZARCHUK

I. Horbachevsky Ternopil National Medical University

Summary:

Drug use is one of the most important causes of liver damage and ranks 3rd after viral diseases and alcohol.

Hepatotoxicity of drugs remains one of the urgent problems of modern medicine, as it leads to a decrease in the effectiveness of pharmacotherapy, development of serious complications that can cause disability and death. Such a side effect increases the length of stay of patients in the hospital and increases the cost of treatment. That is, the problem of hepatotoxicity is not only a medical, but also a social problem.

Research sources focused on modern views about drug hepatotoxicity are reviewed and summarized and new approaches to its prevention and treatment are analyzed.

Conclusions. Hepatotoxicity of drugs remains one of the urgent problems of modern medicine, as it leads to a decrease in the effectiveness of pharmacotherapy, development of serious complications that can cause disability and death. Such a side effect increases the length of stay of patients in the hospital and increases the cost of treatment. That is, the problem of hepatotoxicity is not only a medical, but also a social problem.

Key words: drug hepatotoxicity, measures of its prevention and treatment, new approaches.