The role of exosomes in ischemic stroke

CIECIERSKI-KOŹLAREK, Hubert, ŻUREK, Urszula, TOŁWIŃSKI, Ignacy, KĘDZIERSKA, Zofia, SZWED, Weronika, ANTKOWIAK, Klaudia, DADAS, Klaudia, ŚWIERCZ, Aleksandra, MAŁACHOWSKA, Dominika and SHVED, Kateryna. The role of exosomes in ischemic stroke. Journal of Education, Health and Sport. 2023;28(1):123-137. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.28.01.010

https://apcz.umk.pl/JEHS/article/view/44828

https://zenodo.org/record/8174045

 

 

 

 

 

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of 17.07.2023 No. 32318. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 17.07.2023 Lp. 32318. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2023;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 29.06.2023. Revised: 20.07.2023. Accepted: 20.07.2023. Published: 25.07.2023.

 

 

 

 

 

 

 

The role of exosomes in ischemic stroke

 

Hubert Ciecierski-Koźlarek

Wojewódzki Szpital Specjalistyczny w Olsztynie, ul. Żołnierska 18, 10-561 Olsztyn, Poland

ORCiD: 0009-0009-4062-6888

e-mail: hubertciecierski@icloud.com

 

Urszula Żurek

Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland

ORCiD: 0009-0008-3482-5381

e-mail: ula.zurek@gmail.com

 

Ignacy Tołwiński

Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland

ORCiD: 0000-0003-1362-6734

e-mail: ignacyt233@gmail.com

 

Zofia Kędzierska

Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland

ORCiD: 0000-0002-4181-4719

e-mail: zo.kedzierska@gmail.com

 

 

 

Weronika Szwed

Wojewódzki Szpital Specjalistyczny w Olsztynie, ul. Żołnierska 18, 10-561 Olsztyn, Poland

ORCiD: 0000-0001-9546-7970

e-mail: weronikaszwed1997@gmail.com

 

Klaudia Antkowiak

Szpital Średzki Serca Jezusowego z.o.o ul. Żwirki i Wigury 10, 63-000 Środa Wielkopolska, Poland

ORCiD: 0009-0008-3421-2200

e-mail: klaudia.antkowiak2021@gmail.com

 

Klaudia Dadas

Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland

ORCiD: 0009-0007-3352-9807

e-mail: klaudia.w.2703@gmail.com

 

Aleksandra Świercz

Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland

ORCiD: 0009-0007-1535-1590

e-mail: aleksandra.swiercz1996@gmail.com

 

Dominika Małachowska

Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland

ORCiD: 0009-0008-6305-7959

e-mail: dominika1.malachowska@gmail.com

 

Kateryna Shved

Wielospecjalistyczny Szpital Miejski im. Józefa Strusia, ul. Szwajcarska 3, 61-285 Poznań, Poland

ORCiD: 0009-0002-3773-7025

e-mail: katey.shved@gmail.com

 

 

 

 

Abstract

 

Introduction and purpose: Ischemic stroke is one of the leading causes of death and disability worldwide. There is an urgent need to develop new treatments and diagnosis. The aim of this review is to gather current knowledge on the potential use of exosomes in the diagnosis and treatment of ischemic stroke. This review was based on available data collected in the Pub Med database and Google Scholar web search engine, using the key words: „Exosomes”, „ischemic stroke”

Description of the state of knowledge: Currently, thanks to the development of knowledge about molecular processes, many studies are conducted on drugs that could limit neurodegenerative processes and support repair processes. Many of the drugs that could be used in treatment show poor penetration through the blood-brain barrier. In studies, exosomes show good penetration through the blood-brain barrier, limit neurodegenerative processes and show neuroregenerative effects. Exosomes are characterized by low immunogenicity and toxicity, and the proteins contained in them are involved in neurogenesis, anti-apoptotic processes and synaptic transmission. In addition, studies have shown exosomes inhibit autophagocytosis and reduce neuronal damage.

Summary: Studies performed on animal models have shown the effectiveness of exosomes in the diagnosis and treatment of ischemic stroke. Further studies are needed to determine the efficacy and safety profile of exosomes in humans.

 

Keywords: Exosomes; ischemic stroke; ischemia; microRNA; neurodegenerative processes; neurorestoration